Proliferating cell nuclear antigen (PCNA): a dancer with many partners
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چکیده
منابع مشابه
Proliferating cell nuclear antigen (PCNA): a dancer with many partners.
Proliferating cell nuclear antigen (PCNA) was originally characterised as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the eukaryotic chromosomal DNA replisome. Subsequent studies, however, have revealed its striking ability to interact with multiple partners, which are involved in several metabolic pathways, including Okazaki fragment processing, DNA rep...
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Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA • @polymerase-• Ý • @ that • @is • @ synthesized • @ during • @ the • @ late • @G1 • @ phase through the S phase of cell proliferation. The expression of PCNA correlates strongly with cell proliferation. In the present study, employing NC-012, which is an anti-human PCNA monoclonal antibody, we performed immunohistochemica...
متن کاملProliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation.
BACKGROUND PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast, plant and animal cells that undergo cell division, suggesting a function in cell cycle regulation and/or DNA replication. It subsequently became clear that PCNA also played a role in other processes involving the cell genome. SCOPE This review discusses eukaryotic PCNA, with an emphasis on plant PCNA, ...
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Immunohistochemistry of the S phase related proliferating cell nuclear antigen (PCNA) was studied as an alternative to ex-vivo bromodeoxyuridine (BrdU) immunohistochemistry for assessment of human colonic cell proliferation. From 16 subjects without colonic disease biopsy specimens were collected from five different sites along the colorectum and processed for BrdU and PCNA immunohistochemistry...
متن کاملNuclear distribution of proliferating cell nuclear antigen (PCNA) in fertilized eggs of the starfish Asterina pectinifera.
Previous studies (Nomura et al. (1991) Dev. Biol. 143, 289-296 (1993) Dev. Biol. 159, 288-297) determined the time of DNA replication period (S phase) in starfish eggs fertilized either during or after oocyte maturation. Here proliferating cell nuclear antigen (PCNA) localized within nuclei of starfish eggs was detected with an anti-PCNA human antiserum. Using a confocal laser scanning microsco...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2003
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.00653